Linking Life Science Data: Design to Implementation, and Beyond

Open PHACTS project closing conference (Vienna, Austria)

Poster: Semantic-Web Access to Patent Annotations

SWAT4LS International Conference 2015, Cambridge, UK View poster

Publication: Managing expectations: assessment of chemistry databases generated by automated extraction of chemical structures from patents

First public disclosure of new chemical entities often takes place in patents, which makes them an important source of information. However, with an ever increasing number of patent applications, manual processing and curation on such a large scale becomes even more challenging. An alternative approach better suited for this large…

Poster: Assessing multi target SAR by using pharmacological and pathway data from the public domain

Gordon Research Conference on Computer Aided Drug Design, West Dover, USA View poster

Conference: CiMUS Innopharma Open Innovation Day

CiMUS Innopharma Open Innovation Day, Santiago de Compostela, Spain Stefan Senger (GlaxoSmithKline) gave a presentation: What is Open PHACTS and why would you care?

Presentation: What is Open PHACTS and why would you care?

CiMUS Innopharma Open Innovation Day, Santiago de Compostela, Spain Stefan Senger (GlaxoSmithKline) View presentation

Publication: The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research

Integration of open access, curated, high-quality information from multiple disciplines in the Life and Biomedical Sciences provides a holistic understanding of the domain. Additionally, the effective linking of diverse data sources can unearth hidden relationships and guide potential research strategies. However, given the lack of consistency between descriptors and identifiers…

Publication: Scientific requirements for the next generation semantic web-based chemogenomics and systems chemical biology molecular information system OPS

This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity…

Publication: Incorporating private and commercial data into an open linked data platform for drug discovery

The Open PHACTS Discovery Platform aims to provide an integrated information space to advance pharmacological research in the area of drug discovery. Effective drug discovery requires comprehensive data coverage, i.e. integrating all available sources of pharmacology data. While many relevant data sources are available on the linked open data cloud,…

Publication: Scientific competency questions as the basis for semantically enriched open pharmacological space development

Molecular information systems play an important part in modern data-driven drug discovery. They do not only support decision making but also enable new discoveries via association and inference. In this review, we outline the scientific requirements identified by the Innovative Medicines Initiative (IMI) Open PHACTS consortium for the design of…

Open PHACTS featured in blog posts

Open PHACTS has been featured on the ChEMBL and Corante blogs: ChEMBL blog: Direct submissions of data to ChEMBL and the Open PHACTS project by Stefan Senger Corante blog: In the Pipeline: Why Not Share More Bioactivity Data? by Derek Lowe

Publication: Open data for drug discovery: learning from the biological community

Drug discovery is undergoing a transformational change. Early-stage target identification, lead generation and optimization work is now undertaken in a much more diverse set of organizations, involving biotechnology companies and academia as well as large pharmaceutical companies. Anne Hersey, Stefan Senger, John Overington Full publication: Future Medicinal Chemistry, Volume 4,…

2nd Open PHACTS Community Workshop

Working with Open PHACTS (London, UK)