Conference: KNIME Spring Summit 2016

KNIME Spring Summit 2016, Berlin, Germany Daniela Digles (University of Vienna) presented Creating workflows for drug-discovery with Open PHACTS and KNIME, and George Papadatos (EMBL-EBI) presented Leveraging Open Chemogenomics Data and Tools with KNIME

Publication: Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning

The human ATP binding cassette transporters Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Protein 1 (P-gp) are co-expressed in many tissues and barriers, especially at the blood–brain barrier and at the hepatocyte canalicular membrane. Understanding their interplay in affecting the pharmacokinetics of drugs is of prime interest. In silico tools to predict inhibition and Read more about Publication: Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning[…]

Linking Life Science Data: Final speakers and agenda

There are just three weeks to go until our conference, Linking Life Science Data: From Design to Implementation, and Beyond. If you haven’t yet registered, attendance is free and there are still places available:

Register now

The conference will include a variety of expert speakers and open discussions on linking data in the life sciences domain. The full agenda is now finalised and we look forward to seeing you there.

We are also pleased to present the submissions for our poster competition, which will be held at the conference on the evening of 18 February. See below for the list of entrants and poster abstracts.

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Conference: Österreichische Apothekerkammer 47th Scientific training event

Österreichische Apothekerkammer 47th Scientific training event for pharmacists, Schladming, Austria Daniela Digles (University of Vienna) presented a poster: Answering drug-discovery research questions with Open PHACTS and KNIME

Publication: The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research

Integration of open access, curated, high-quality information from multiple disciplines in the Life and Biomedical Sciences provides a holistic understanding of the domain. Additionally, the effective linking of diverse data sources can unearth hidden relationships and guide potential research strategies. However, given the lack of consistency between descriptors and identifiers used in different resources and Read more about Publication: The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research[…]

Publication: Transporter taxonomy – a comparison of different transport protein classification schemes

Currently, there are more than 800 well characterized human membrane transport proteins (including channels and transporters) and there are estimates that about 10% (approx. 2000) of all human genes are related to transport. Membrane transport proteins are of interest as potential drug targets, for drug delivery, and as a cause of side effects and drug–drug Read more about Publication: Transporter taxonomy – a comparison of different transport protein classification schemes[…]