EU-ToxRisk: An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century
(PDF) In a large (€30 m) H2020-supported collaborative project, academia joins forces with small and medium-sized enterprises (SMEs), large industry, contract research organisations (CROs) and regulatory bodies to achieve a paradigm shift in toxicology towards a more efficient and animal-free chemical safety assessment.
(PDF) Vienna, Austria – The Open PHACTS consortium is proud to have been awarded first prize in the Linked Open Data Award category of the European Linked Data Contest (ELDC).
The ELDC has been established to recognise Europe’s crème de la crème of linked data and semantic web achievements. Prizes are awarded to stories, products, projects or persons presenting novel and innovative projects, products and industry implementations involving linked data. The ELDC also aims to build a directory of the best European projects in the domains of linked data and the semantic web.
(PDF) Cambridge, UK – The not-for-profit Open PHACTS Foundation announced its first three members today – GlaxoSmithKline, Janssen and Roche – who will steer the future of the successor organisation to the Innovative Medicines Initiative (IMI)- funded Open PHACTS project.
The commitment by these global pharmaceutical industry members signifies a major step in ensuring the sustainability of infrastructure developed during the Open PHACTS project.
(PDF) London, UK – The Open PHACTS Community Workshop was held at Burlington House in London on April 22 and 23, 2013. The workshop was intended to feature the public release of the Open PHACTS API and the first Open PHACTS example apps, ChemBioNavigator and PharmaTrek. The event was also held to outline the project sustainability Read more about Press Release: Open PHACTS Community Workshop: “Using the power of Open PHACTS”[…]
(PDF) Cambridge, UK – The Open PHACTS consortium is pleased to announce a new project partner. OpenLink Software has been selected to be the Linked Data hosting provider for the online Open PHACTS platform, leveraging its well known experience in hosting high-performance and scalable linked data spaces via its Virtuoso platform for multi-model data management and integration.
(PDF) Cambridge, UK – The Open PHACTS consortium is pleased to announce an Associate Partner relationship with Eagle Genomcis Ltd. (Eagle). Eagle intend to work with the consortium members to interface Open PHACTS with genomics tools (e.g. the Ensembl Browser) and workflows (e.g. Hive/Galaxy), and also facilitate the integration of data from major genomics references databases (e.g. Ensembl) into Open PHACTS data stores. Eagle is a leading provider of bioinformatics services to the entire life sciences and biotechnology industry and have established a strong reputation as experts in the field of genomic data analysis and integration. Richard Holland, Chief Business Officer of Eagle, comments “Eagle’s recent experiences in semantic web research combined with our long track record in delivering genomic data analysis solutions to the pharmaceuticals industry mean that we are well placed to make a valuable contribution to the work of the Open PHACTS consortium. We are excited about the potential of this project and the opportunities it opens up for the application of semantic web technology to accelerating drug discovery research.”
(PDF) The Open PHACTS consortium is pleased to announce that ConnectedDiscovery, the European Bioinformatics Institute, Janssen, the Netherlands Bioinformatics Centre, and the Swiss Institute of Bioinformatics have joined the project as new consortium members.
The addition of these partners – bringing together respected drug discovery and bioinformatics expertise from academic institutions, a small start-up, and an EFPIA company – demonstrates the progress and promise of this project as it nears its halfway point.
(PDF) The Open PHACTS consortium is pleased to announce an Associate Partner relationship with Advanced Chemistry Development, Inc. (ACD/Labs) who will be supplying a number of predicted physicochemical properties for inclusion within the project data. ACD/Labs is one of the primary suppliers of prediction algorithms to the life sciences industry and their contribution of data provides enhanced querying options for the users. Daria Thorp, President of ACD/Labs, comments “The Open PHACTS project represents a promising approach that leverages existing pharmacological knowledge to make new discoveries. ACD/Labs, with our 18 years of in silico physicochemical and ADME-Tox modeling experience, is excited to provide our industry leading molecular property predictions notably logD at physiologically relevant pH, “rule of 5”, and logP values to this project.” The ACD/Labs data will be offered via RSC ChemSpider which provides the chemical compound data in a format consumable by the Open PHACTS platform.
(PDF) Aims & Scope of this Guidelines This document outlines the relationship between the Open PHACTS System (OPS, see http://www.openphacts.org/) and a semantic data model called nanopublications. The primary aim is to define the format and organisation of nanopublications suitable for inclusion in OPS. This document also clarifies the relationship between nanopublications and “standard RDF” Read more about Press Release: Open PHACTS releases nanopublication guidelines[…]
(PDF) Vienna, Austria – A new consortium of European organisations unite to support next generation drug discovery by providing a single view across data sources, bringing the semantic web to drug discovery.
The Open PHACTS consortium, funded by the Innovative Medicines Initiative, will reduce the barriers to drug discovery by applying semantic technologies to available data resources, creating an Open Pharmacological Space.