17th October 2017

The Platform

Coming soon: API version 3.0! Watch this space or sign up for our newsletter to be the first to hear about our upcoming data refresh and architecture updates.

Key Facts about Open PHACTS

“Integration of different databases is difficult, costly, and time consuming, and probably would not have been done at this level of quality without Open PHACTS.”

–Herman van Vlijmen, Janssen Pharmaceutica

Using Open PHACTS


All Open PHACTS data can be accessed and queried via our commercial-grade API. Anyone can register for a free API key via our API portal and start querying the data provided by Open PHACTS.

We’ve served over 500 million queries since the platform went live in 2013, and are constantly working to update and add to our API calls and datasets.

Access the API web portal

Workflow Tools

Want to integrate Open PHACTS queries directly into your existing workflows? Thanks to collaborations with Pipeline Pilot, KNIME, and many members of the Open PHACTS community, we have a collection of Pipeline Pilot components and dedicated KNIME nodes which offer access to Open PHACTS data through your workflow tool of choice. Try them out at the links below, or take a look at our workflow templates for examples of how they can be used to answer research queries.

Pipeline Pilot Collection   KNIME Nodes on GitHub


We’ve worked with database owners to confirm that anyone may access, interact with and analyse data through the Open PHACTS platform for research and development—including development and commercialisation of pharmaceuticals.

For other purposes, such as downloading datasets in full, you’ll need to refer to the individual dataset licences provided in the table below.

Data Sources

We recognise how important it is for researchers to know exactly what data they’re working with. This table below lists all data sources available via the latest Open PHACTS API, version 2.2. Metadata about data provenance is also integrated into Open PHACTS, so you can always verify exactly where the information you see comes from.

BioAssay OntologyCC-BY 3.0
CALOHACC-BY 3.02014-01-2208 Apr 2015
ChEBICC-BY-SA 3.0Release 12504 Mar 2015
ChEMBLCC-BY-SA 3.0ChEMBL 23Jan 2018
ConceptWikiCC-BY-SA12 Dec 2013
Disease OntologyCC-BY2015-05-21
DisGeNETOpen Database LicenseVersion 2.1.031 Mar 2015
DrugBankCC-BY-NC 4.0Version 4.119 Feb 2015
ENZYMENo modificationsMay 2017
FDA Adverse Events (FAERS)CC0 (Public Domain)09 Jul 2012
Gene OntologyCC-BY 4.004 Mar 2015
Gene Ontology AnnotationsCC-BY 4.017 Feb 2015
neXTProtCC-BY-ND 3.0v1.001 Feb 2014
Open PHACTS Chemical Registry
- MeSH
- PDB Ligands

- 2.6
- 2015
- 2
04 Nov 2014
Open PHACTS MetadataCC-BY-SA
SureChEMBLTermsMar 2015
UniProtCC-BY-ND 3.0May 2017
WikiPathwaysCC-BY 3.0Mar 2017

Chemical compounds from these sources are validated and normalised through the Open PHACTS Chemical Registry, which also integrates identifiers and adds synonyms from ChemSpider. Physicochemical properties are predicted by the ACD/Labs Percepta Platform.


Want to know more? Take a look at our Support Portal, or get in touch with CTO Nick Lynch!