Coming soon: API version 3.0! Watch this space or sign up for our newsletter to be the first to hear about our upcoming data refresh and architecture updates.
Key Facts about Open PHACTS
- Open PHACTS brings together data sources you already use, integrated and linked so that you can easily see the relationships between compounds, targets, pathways, diseases and tissues.
- Data sources include ChEBI, ChEMBL, SureChEMBL, ChemSpider, ConceptWiki, DisGeNET, DrugBank, Gene Ontology, neXtProt, UniProt and WikiPathways.
- Open PHACTS can be used to answer complex questions in drug discovery—we’ve demonstrated how in peer-reviewed publications.
- We built Open PHACTS in collaboration with a large consortium of major academic and commercial organisations involved in drug discovery.
- Open PHACTS is founded on semantic web and linked data principles and uses industrial-strength tools to provide fast and robust access to the data sources you trust.
- Data is available in a variety of formats to suit the applications you already use, including JSON, XML, TSV and RDF.
“Integration of different databases is difficult, costly, and time consuming, and probably would not have been done at this level of quality without Open PHACTS.”
–Herman van Vlijmen, Janssen Pharmaceutica
Using Open PHACTS
We’ve served over 500 million queries since the platform went live in 2013, and are constantly working to update and add to our API calls and datasets.
For other purposes, such as downloading datasets in full, you’ll need to refer to the individual dataset licences provided in the table below.
We recognise how important it is for researchers to know exactly what data they’re working with. This table below lists all data sources available via the latest Open PHACTS API, version 2.2. Metadata about data provenance is also integrated into Open PHACTS, so you can always verify exactly where the information you see comes from.
|BioAssay Ontology||CC-BY 3.0|
|CALOHA||CC-BY 3.0||2014-01-22||08 Apr 2015|
|ChEBI||CC-BY-SA 3.0||Release 125||04 Mar 2015|
|ChEMBL||CC-BY-SA 3.0||ChEMBL 23||Jan 2018|
|ConceptWiki||CC-BY-SA||12 Dec 2013|
|DisGeNET||Open Database License||Version 2.1.0||31 Mar 2015|
|DrugBank||CC-BY-NC 4.0||Version 4.1||19 Feb 2015|
|ENZYME||No modifications||May 2017|
|FDA Adverse Events (FAERS)||CC0 (Public Domain)||09 Jul 2012|
|Gene Ontology||CC-BY 4.0||04 Mar 2015|
|Gene Ontology Annotations||CC-BY 4.0||17 Feb 2015|
|neXTProt||CC-BY-ND 3.0||v1.0||01 Feb 2014|
|Open PHACTS Chemical Registry br>|
- PDB Ligands
|04 Nov 2014|
|Open PHACTS Metadata||CC-BY-SA|
|UniProt||CC-BY-ND 3.0||May 2017|
|WikiPathways||CC-BY 3.0||Mar 2017|
Chemical compounds from these sources are validated and normalised through the Open PHACTS Chemical Registry, which also integrates identifiers and adds synonyms from ChemSpider. Physicochemical properties are predicted by the ACD/Labs Percepta Platform.