
Poster: Open PHACTS Use Cases
EFMC-ISMC 2012, 22nd International Symposium on Medicinal Chemistry, Berlin, Germany View poster
Publication: Open data for drug discovery: learning from the biological community
Drug discovery is undergoing a transformational change. Early-stage target identification, lead generation and optimization work is now undertaken in a much more diverse set of organizations, involving biotechnology companies and academia as well as large pharmaceutical companies. Anne Hersey, Stefan Senger, John Overington Full publication: Future Medicinal Chemistry, Volume 4,…
Publication: Druggable and biopharmable genome annotation pipeline development
The identification of proteins which could be potential targets for new pharmaceutical products is invaluable for the continued improvement people’s quality of life and expansion of available treatment options. In order to aid the discovery of new drug targets, predictions of every human gene likely to be exploitable by compounds…
Poster: Open PHACTS Architecture: Building the extensible platform
19th EuroQSAR, Knowledge Enabled Ligand Design, Vienna, Austria View poster
Poster: Open PHACTS Scientific Competency Questions: Guiding the technical development
19th EuroQSAR, Knowledge Enabled Ligand Design, Vienna, Austria View poster
Poster: Open PHACTS Examplars: Using the Open PHACTS Platform API
19th EuroQSAR, Knowledge Enabled Ligand Design, Vienna, Austria View poster
Publication: The Pharmacology Workspace: A Platform for Drug Discovery
We present the Open PHACTS linked data platform that is being developed to address a set of example drug discovery research questions and which supports several drug discovery applications. The platform retrieves data from many complementary, but overlapping, data sources to present an integrated view of the data. The platform…
Presentation: The Open Pharmacological Concepts Triple Store
IMI Stakeholder Forum 2012, Brussels, Belgium Bryn Williams-Jones (Connected Discovery), Gerhard Ecker (University of Vienna) View presentation
Publication: Towards a gold standard: regarding quality in public domain chemistry databases and approaches to improving the situation
In recent years there has been a dramatic increase in the number of freely accessible online databases serving the chemistry community. The internet provides chemistry data that can be used for data-mining, for computer models, and integration into systems to aid drug discovery. There is however a responsibility to ensure…
Presentation: Open PHACTS: an introduction and explanation
Information on the Open PHACTS Project View presentation
Publication: The Innovative Medicines Initiative: A European Response to the Innovation Challenge
The Innovative Medicines Initiative (IMI) was launched in 2008 as a large-scale public–private partnership between the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA). With a total budget of €2 billion, the IMI aims to boost the development of new medicines across Europe by implementing new…
Publication: It’s all about the data: an exclusive interview with Dr. Antony J. Williams
Thousands of professionals in the life sciences and other industries rely on external chemical data in their decision matrices. Just how reliable is publicly available data? Don Alexander of Carlyle & Conlan interviewed Dr. Antony J. Williams for perspective on this issue. Antony J. Williams Full publication: Life Science Trends…
Publication: Toward interoperable bioscience data
To make full use of research data, the bioscience community needs to adopt technologies and reward mechanisms that support interoperability and promote the growth of an open ‘data commoning’ culture. Here we describe the prerequisites for data commoning and present an established and growing ecosystem of solutions using the shared…
Publication: Of possible cheminformatics futures
For over a decade, cheminformatics has contributed to a wide array of scientific tasks from analytical chemistry and biochemistry to pharmacology and drug discovery; and although its contributions to decision making are recognized, the challenge is how it would contribute to faster development of novel, better products. Here we address…
Publication: Representing Text Mining Results for Structured Pharmacological Queries
Several approaches integrating life science data using Semantic Web technologies have been described in the literature. However, these approaches have largely ignored the vast amount of content only available within the scientific literature. In this article, we present an RDF schema for text mining results that enables queries in SPARQL…
Presentation: Integrating and curating internet based chemistry resources to serve life scientists
PharmSciFair 2011, Prague, Czech Republic Antony Williams (Royal Society of Chemistry) View presentation